Regular swimming before the induction of ulcer ameliorates oxidative gastric damage in rats: The anxiolytic effect of exercise



Objectives: To investigate the impact of exercise on ulcerogenesis.
Materials and Methods: Gastric ulcer was induced in Wistar
albino rats that were either kept sedentary or had swimming
exercise for 6 weeks. Under anesthesia, ulcer was induced by
applying acetic acid on the stomach serosa, while control rats had
sham-operation. On 3rd or 10th days of ulcer induction, anxiety
levels were measured and rats were decapitated for measuring
serum cortisol level, while gastric tissue samples were obtained for
histopathologic analysis and for determination of malondialdehyde
(MDA), glutathione (GSH) levels, myeloperoxidase (MPO)
activity, luminol- and lucigenin-enhanced chemiluminescence
(CL) and nitric oxide (NO) levels.
Results: In sedentary 3-day-ulcer group, gastric MPO activities
were elevated with concomitant reductions in GSH content, while
these changes were reversed in 10-day ulcer group. In exercised
3-day-ulcer group, all parameters were significantly reversed.
Increased lucigenin-CL was suppressed, while NO levels were
elevated by exercise. Histological analysis revealed lower lesion
scores in exercised groups. Serum cortisol levels were not different
among ulcer groups, but anxiety was suppressed by swimming
exercise in 3-day-ulcer group.
Conclusion: Regular swimming exercise ameliorated acetic
acid-induced oxidative damage of stomach via inhibition of
neutrophil infiltration and through anti-stress effect of exercise.
Regular exercise may be considered in facilitating the healing of
gastric ulcers.
Keywords: Acetic acid, Gastric ulcer, Exercise, Myeloperoxidase,



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