Diffusion-weighted MRI: In differential diagnosis of liver masses
Objectives: The purpose of our study was to determine apparent
diffusion coefficients (ADCs) of focal liver lesions on the basis of
respiratory triggered diffusion-weighted single-shot echo-planar
MR imaging (DWI-SS-EPI) sequence and to evaluate whether
ADC measurements can be used to characterize lesions.
Patients and Methods: One hundred and eighteen patients with
134 focal liver lesions [35 cysts, 48 hemangiomas, 4 focal noduler
hyperplasias (FNH), 31 metastases, 14 hepatocellular carsinomas
(HCCs), 1 fibrolamellar carsinoma, 1 cholangiocellular carcinoma;
mean size 18.4 mm; range 10-140 mm] were examined on a 1.5-T
system using respiratory triggered DWI-SS-EPI (b-values: 50, 400,
Results: Results were correlated with characteristic MRI
findings, histopathologic data and follow-up imagings. The
ADCs of different lesion types were compared and lesion
differentiation using optimal thresholds for ADCs was evaluated.
Mean ADCs (x10-3 mm2/s) were 2.15, 1.57, 1.16, 1.08, 1.03 for
cysts, hemangiomas, FNHs, metastases and HCCs, respectively.
Mean ADCs differed significantly for all lesion types except
metastases, HCCs and FNHs. Overall, 88.5% of lesions were
correctly classified as benign or malignant using a treshold value
Tam metin:PDF (English)
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