Griscelli Syndrome and Periodontal Therapy Approach: a Case Report

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Griscelli Syndrome (GS), a rare autosomal recessive genetic
disorder characterized with pigmentary dilution of the skin,
malfunctions of humoral and cellular immunity, was first described
by Claude Griscelli in 1978. In this report, periodontal therapy and
follow-up of a 10 year-old girl with GS type 2, who applied to our
clinic with complaints of gingival bleeding and redness, was
presented. The patient had silvery-grey coloured hair and eyebrow,
well-rounded nose radix and tip, and hemiparesthesia at the right
part of her body. Intraoral examination revealed pigmentation of
the lips, heavy accumulation of microbial dental plaque, hyperemia
and edema at gingiva. She was diagnosed with plaque-induced
gingivitis, and initial periodontal treatment including oral hygiene
instructions, scaling and polishing was performed under
recommended antibiotic prophylaxis. She was followed up with 1
month intervals. After 6 months, she attended to the clinic with
clinical signs of acute necrotizing ulcerative gingivitis and was
treated with diluted hydrogen peroxide and chlorhexidine
digluconate (0.2%) rinse. Due to the hyperactivity of T lymphocytes
and macrophages, intensive host response to dental plaque in
patients with GS can be seen. In conclusion, importance of oral
hygiene should be emphasized in establishing high level of oral
health and, maintenance of patients with GS should be carried out
with short intervals.


Griscelli syndrome type 2; nonsurgical periodontal debridement; acute necrotizing ulcerative gingivitis

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