Salivary Thromboplastic Activity in Children with Cancer

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Thromboplastin is a membrane bound glycoprotein and it is
overexpressed in many cancer cells. Chemotherapy induce some
alterations in either saliva composition or function leading to oral
complications. The aim of this study was to investigate the salivary
thromboplastic activity of children with cancer and to compare
with healthy children. Saliva samples were taken from 15 children
who were diagnosed with lymphoid and solid tumor and from 15
healthy children. In saliva samples thromboplastic activity and
total protein levels were determined and SDS polyacrylamide gel
electrophoresis was also carried out with these saliva samples. For
cytological examination, imprint samples were prepared by
applying a drop of saliva on a slide. Salivary thromboplastic
activity of children with cancer (CC) was significantly decreased
when compared with the healthy children (HC). pH of the saliva in
CC was significantly decreased. Salivary flow rate did not
significantly change in CC. Saliva total protein level was
significantly decreased in CC when compared to HC. In SDS
PAGE electrophoresis, some protein bands decreased and some
protein bands increased when the two group is compared. In
cytologic evaluation of saliva samples, keratinized and dysplastic
cells increased in the imprint samples of CC. It should be noted
that children receiving chemotherapy encounter major problems
in oral and dental health, therefore they need special preventive
programs for their oral and dental health.


Saliva, thromboplastic activity, pH, cancer, salivary cells

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